Publications | Ruth Palmer Lab

RUVBL1 and RUVBL2 are druggable MYC effector regulators in neuroblastoma cells

Fri, 17 Apr 2026 00:00:00 +0000

Novel activating SNRNP70-ALK fusion in congenital infant-type hemispheric glioma displays clinical response to lorlatinib: a case-report

Thu, 26 Feb 2026 00:00:00 +0000

Spatial transcriptomics exploration of the primary neuroblastoma microenvironment in archived FFPE samples unveils novel paracrine interactions

Wed, 01 Oct 2025 00:00:00 +0000

Alk(Tango) reveals a role for Jeb/Alk signaling in the Drosophila heart

Sat, 17 May 2025 00:00:00 +0000

The Alk receptor tyrosine kinase regulates Sparkly, a novel activity regulating neuropeptide precursor in the Drosophila central nervous system

Fri, 21 Jun 2024 00:00:00 +0000

Anaplastic Lymphoma Kinase signaling stabilizes SLC3A2 expression via MARCH11 to promote neuroblastoma cell growth

Mon, 10 Jun 2024 00:00:00 +0000

Comparison of (177)Lu-octreotate and (177)Lu-octreotide for treatment in human neuroblastoma-bearing mice

Thu, 30 May 2024 00:00:00 +0000

Preclinical exploration of the DNA damage response pathway using the interactive neuroblastoma cell line explorer CLEAN

Thu, 11 Jan 2024 00:00:00 +0000

ALK F1174S mutation impairs ALK kinase activity in EML4-ALK variant 1 and sensitizes EML4-ALK variant 3 to crizotinib

Tue, 09 Jan 2024 00:00:00 +0000

ALK signaling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition

Tue, 02 Jan 2024 00:00:00 +0000

IGF1R Contributes to Cell Proliferation in ALK-Mutated Neuroblastoma with Preference for Activating the PI3K-AKT Signaling Pathway

Fri, 25 Aug 2023 00:00:00 +0000

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In vivo Characterization of Endogenous Protein Interactomes in Drosophila Larval Brain, Using a CRISPR/Cas9-based Strategy and BioID-based Proximity Labeling

Mon, 05 Jun 2023 00:00:00 +0000

ALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses via SERPINB4 expression

Tue, 21 Feb 2023 00:00:00 +0000

Novel human-derived EML4-ALK fusion cell lines identify ribonucleotide reductase RRM2 as a target of activated ALK in NSCLC

Thu, 01 Sep 2022 00:00:00 +0000

Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival

Mon, 01 Aug 2022 00:00:00 +0000

The autocrine loop of ALK receptor and ALKAL2 ligand is an actionable target in consensus molecular subtype 1 colon cancer

Tue, 29 Mar 2022 00:00:00 +0000

Sustained Response to Entrectinib in an Infant With a Germline ALKAL2 Variant and Refractory Metastatic Neuroblastoma

Sat, 01 Jan 2022 00:00:00 +0000

DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as an Alk target in the Drosophila visceral mesoderm

Wed, 01 Dec 2021 00:00:00 +0000

ATR inhibition enables complete tumour regression in ALK-driven NB mouse models

Wed, 24 Nov 2021 00:00:00 +0000

Chromosome Imbalances in Neuroblastoma—Recent Molecular Insight into Chromosome 1p-deletion, 2p-gain, and 11q-deletion Identifies New Friends and Foes for the Future

Wed, 24 Nov 2021 00:00:00 +0000

In vivo Profiling of the Alk Proximitome in the Developing Drosophila Brain

Fri, 19 Nov 2021 00:00:00 +0000

Mapping the Phospho-dependent ALK Interactome to Identify Novel Components in ALK Signaling

Fri, 19 Nov 2021 00:00:00 +0000

BioID-Screening Identifies PEAK1 and SHP2 as Components of the ALK Proximitome in Neuroblastoma Cells

Fri, 17 Sep 2021 00:00:00 +0000

Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration

Tue, 13 Jul 2021 00:00:00 +0000

Loss of RET Promotes Mesenchymal Identity in Neuroblastoma Cells

Thu, 15 Apr 2021 00:00:00 +0000

ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation

Mon, 01 Feb 2021 00:00:00 +0000

11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma

Tue, 22 Sep 2020 00:00:00 +0000

Identification of the Wallenda JNKKK as an Alk suppressor reveal increased competitiveness of Alk-expressing cells

Fri, 11 Sep 2020 00:00:00 +0000

Analysis of ALK, MYCN, and the ALK ligand ALKAL2 (FAM150B/AUGalpha) in neuroblastoma patient samples with chromosome arm 2p rearrangements

Wed, 01 Jan 2020 00:00:00 +0000

Repotrectinib (TPX-0005) effectively reduces growth of ALK-driven neuroblastoma cells

Wed, 18 Dec 2019 00:00:00 +0000

Targeting anaplastic lymphoma kinase in neuroblastoma

Wed, 01 May 2019 00:00:00 +0000

Alectinib, an Anaplastic Lymphoma Kinase Inhibitor, Abolishes ALK Activity and Growth in ALK-Positive Neuroblastoma Cells

Tue, 01 Jan 2019 00:00:00 +0000

Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways

Tue, 20 Nov 2018 00:00:00 +0000

Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor ceritinib

Wed, 01 Aug 2018 00:00:00 +0000

ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells

Tue, 23 Jan 2018 00:00:00 +0000

MEK inhibitor trametinib does not prevent the growth of anaplastic lymphoma kinase (ALK)-addicted neuroblastomas

Tue, 28 Nov 2017 00:00:00 +0000

Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma Mutation

Mon, 30 Oct 2017 00:00:00 +0000

The scaffolding protein Cnk binds to the receptor tyrosine kinase Alk to promote visceral founder cell specification in Drosophila

Tue, 24 Oct 2017 00:00:00 +0000

The Zic family homologue Odd-paired regulates Alk expression in Drosophila

Sat, 01 Apr 2017 00:00:00 +0000

The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and MYCN

Thu, 01 Sep 2016 00:00:00 +0000

Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice

Tue, 17 May 2016 00:00:00 +0000

FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase

Tue, 29 Sep 2015 00:00:00 +0000