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Targeting anaplastic lymphoma kinase in neuroblastoma
Ganesh Umapathy
,
Patricia Mendoza Garcia
,
Ruth Palmer
PDF
DOI
Alectinib, an Anaplastic Lymphoma Kinase Inhibitor, Abolishes ALK Activity and Growth in ALK-Positive Neuroblastoma Cells
Muhammad Wasi Alam
,
Marcus Borenäs
,
Dan Emil Lind
,
Diana Cervantes-Madrid
,
Ganesh Umapathy
,
Ruth Palmer
PDF
DOI
Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways
Jimmy Van den Eynden
,
Ganesh Umapathy
,
Arghavan Ashouri
,
Diana Cervantes-Madrid
,
Joanna Szydzik
,
Kristina Ruuth
,
Jan Koster
,
Erik Larsson
,
Jikui Guan
,
Ruth Palmer
PDF
DOI
Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor ceritinib
Jikui Guan
,
Susanne Fransson
,
Joachim Tetteh Siaw
,
Diana Treis
,
Jimmy Van den Eynden
,
Damini Chand
,
Ganesh Umapathy
,
Kristina Ruuth
,
Petter Svenberg
,
Sandra Wessman
,
Alia Shamikh
,
Hans Jacobsson
,
Lena Gordon
,
Jakob Stenman
,
Par-Johan Svensson
,
Magnus Hansson
,
Erik Larsson
,
Per Kogner
,
Ruth Palmer
PDF
DOI
ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells
Andrey Fadeev
,
Patricia Mendoza Garcia
,
Uwe Irion
,
Jikui Guan
,
Kathrin Pfeifer
,
Stephanie Wiessner
,
Fabrizio Serluca
,
Ajeet Pratap Singh
,
Christiane Nusslein-Volhard
,
Ruth Palmer
PDF
DOI
MEK inhibitor trametinib does not prevent the growth of anaplastic lymphoma kinase (ALK)-addicted neuroblastomas
Ganesh Umapathy
,
Jikui Guan
,
Dan E. Gustafsson
,
Niloufar Javanmardi
,
Diana Cervantes-Madrid
,
Anna Djos
,
Tommy Martinsson
,
Ruth Palmer
PDF
DOI
Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma Mutation
Jikui Guan
,
Yasuo Yamazaki
,
Damini Chand
,
Jesper Van Dijk
,
Kristina Ruuth
,
Ruth Palmer
PDF
DOI
The scaffolding protein Cnk binds to the receptor tyrosine kinase Alk to promote visceral founder cell specification in Drosophila
Georg Wolfstetter
,
Kathrin Pfeifer
,
Jesper R. van Dijk
,
Fredrik Hugosson
,
Xiangyi Lu
,
Ruth Palmer
PDF
DOI
The Zic family homologue Odd-paired regulates Alk expression in Drosophila
Patricia Mendoza Garcia
,
Fredrik Hugosson
,
Mahsa Fallah
,
Michael L. Higgins
,
Yasuno Iwasaki
,
Kathrin Pfeifer
,
Georg Wolfstetter
,
Gaurav Varshney
,
Dmitry Popichenko
,
J. Peter Gergen
,
Korneel Hens
,
Bart Deplancke
,
Ruth Palmer
PDF
DOI
The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and MYCN
Jikui Guan
,
E. R. Tucker
,
Haiying Wan
,
Damini Chand
,
L. S. Danielson
,
Kristina Ruuth
,
Abeer El Wakil
,
Barbara Witek
,
Y. Jamin
,
Ganesh Umapathy
,
S. P. Robinson
,
T. W. Johnson
,
T. Smeal
,
Tommy Martinsson
,
L. Chesler
,
Ruth Palmer
PDF
DOI
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